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Amlodipine is a calcium channel blocker used for the treatment of hypertension, angina, and for angina due to coronary artery disease in patients without heart failure of an ejection fraction of less than 40%.

In general, treatment with amlodipine besylate tablets were well-tolerated at doses up to 10 mg daily.

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Further, albuminuria decreased with losartan-based therapy but increased with amlodipine-based therapy, and the differences were statistically significant.

Some benazepril-treated hypertensive patients with no apparent preexisting renal vascular disease have developed increases in blood urea nitrogen and serum creatinine, usually minor and transient, especially when benazepril has been given concomitantly with a diuretic.

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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amlodipine only for the indication prescribed.

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Other lab abnormalities may include increased blood creatinine levels and hyperkalemia (olmesartan medoxomil), hepatic enzyme elevations (amlodipine), and increased cholesterol and triglyceride levels (HCTZ).

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Vasospastic Angina: amlodipine has been demonstrated to block constriction and restore blood flow in coronary arteries and arterioles in response to calcium, potassium epinephrine, serotonin, and thromboxane A2 analog in experimental animal models and in human coronary vessels in vitro.

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Second, if we assume that one third of our nonischemic patients had coronary artery disease and that these patients were entirely responsible for the treatment differences we observed, we would need to postulate that amlodipine almost completely prevented deaths among these misclassified patients.

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Of the 4285 patients enrolled, 2271 were randomly assigned to double-blind treatment, and 2060 completed the study ().

On the other hand, they describe the increased incidence of adverse reactions, such as pulmonary edema, using the difference in absolute risk, which minimizes the difference.

No satisfactory explanation was provided for this unexpected result.

Amlodipine was discontinued and replaced with ramipril (an ACE inhibitor).

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